This is a common question, and the answer is simply, no. In fact, some IRS estimates place the acceptance rate of a second offer in compromise (using figures and tips the IRS offer examiner puts in the rejection letter back to you) as high as 75%.
The only real downside to submitting multiple offers is the up-front payment required to submit an offer by the Tax Increase Prevention & Reconciliation Act of 2005 (TIPRA). TIPRA requires a $150 processing fee (except for low income taxpayers) and 20% of the offered amount to be paid with the application. If you are submitting a 24 month offer you must begin your proposed periodic payment. The TIPRA down payment is non-refundable, if your offer is rejected. If you are filing another offer, you must submit another TIPRA payment.
Call Norman and Oklahoma City tax attorney Travis Watkins at 800-721-7054 for more information about the offer in compromise process.